symptoms of gadolinium toxicity

He said that it is imperative that individuals have at least 3 of the symptoms, but he prefers to see 5/6 to be certain of the diagnosis. A recent study by Radbruch et al. Read our full post and the study here. The FDA warning that came in 2015 was the one gadolinium toxicity advocates like Marcie were fighting for. einzuordnen. As more research was performed and more patient data was gathered, the evidence and understanding of what retained gadolinium can do to the human body has increased significantly. This study provides the first definitive evidence that GBCAs induce mitochondrial toxicity and cell death in cultured human neurons. Can Symptoms of Gadolinium Toxicity be explained? Sharon Williams (A pdf of this Editorial is available for download). 4. The long-term and cumulative effects of retained gadolinium in the brain and elsewhere are not as yet understood. So the good news is that there are relatively few commercial uses for this dangerous metal and its compounds (1). As Marckmann pointed out, “supporting evidence of the causal relationship between GBCA and NSF comes from ex vivo and animal studies demonstrating that Gd-salts and some GBCAs cause histologic and clinical effects resembling what is seen in NSF“. The word “nephrogenic” in the name caused doctors and researchers to focus on people with severe renal disease. It describes “phases of NSF” and a “severity grading”, and the paper highlights the differences between early and late manifestations of the disease. MRT & Gadolinium; Symptome; Hilfen; FAQ; Pharmalobby; Interessengemeinschaft; Blog & News; Helfen Sie! Less serious side effects nausea, headache and dizziness. They divided the clinical course of “GBCA-induced NSF” into 4 phases: latent (0-14 days after GBCA exposure with a range of 0-60 days), early inflammatory (14-60 days after GBCA with a range of 0-60 days), intermediate (60-180 days after GBCA exposure), and late fibrotic (+180 days after GBCA exposure). The problem has nothing to do with patients’ kidneys, but everything to do with retained gadolinium – a toxic metal like lead or mercury. However, the lack of physical evidence and abnormal blood tests does not mean that harmful events have not taken place in patients’ bodies. Gadolinium Toxicity Symptoms. Our only advice is to consider symptom relief carefully, and do not try to be the hero who says “I … There was a significantly larger decrease of IEFND for the linear GBCAs compared to macrocyclic GBCAs. Researchers and the FDA want scientific evidence and not just anecdotal facts compiled from patients who have been affected by retained gadolinium. What we don’t know is how much they retain. The authors noted that the cause of SFN remains unknown in up to 50% of cases. is available for download as a PDF and it will be posted in Our Research in the Research section of our website. 2. Often the joints may be peripheral but can also be large joints like the knee or hip. The updated graphs show an even stronger pattern of Gadolinium urine levels based on the number of months since the participant’s last Contrast MRI. It shouldn’t matter whether the evidence comes from unenhanced brain MR images, gadolinium detected in biopsy specimens, prolonged gadolinium excretion in urine specimens, or other testing methods. Those with gadolinium toxicity present symptoms shortly after a contrast MRI. Toxicity is rarely associated with Gd due to its poor gastrointestinal absorption (it is suspected that very little Gd is absorbed from the gastrointestinal tract (<0.05%). 2019 Apr;29(4):1922-1930. doi: 10.1007/s00330-018-5737-z. Brain fog is also a prominent feature of lead toxicity, which is another heavy metal toxicity. Gadolinium was Retained in the Spinal Cord & Peripheral Nerves of Rats We now know from the literature that every patient who has an MRI with contrast likely retains gadolinium. Gadolinium deposition disease refers to situations in which a person has normal or adequate renal function but develops persistent and/or painful symptoms anywhere from a few hours to several weeks after being injected with a gadolinium contrast agent. Gadolinium Toxicity – Let’s not make the same mistake again, http://ard.bmj.com/content/69/11/1895.full.pdf, http://www.ncbi.nlm.nih.gov/pubmed/19744598, https://vdocuments.mx/nsf-clinical-picture-treatment.html, http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2853020&tool=pmcentrez&rendertype=abstract, https://gdtoxicity.files.wordpress.com/2016/10/swilliams-2012fda-letter-gdtoxicity1.pdf, Gadolinium Toxicity – Let’s not make the same mistake again. Brain fog. These symptoms include brain fog, cognitive deficits, burning pain throughout the body, bone pain, joint pain, skin changes and hair loss. On August 25, 2020, I wrote an open letter to the FDA, Radiologists and Researchers about the symptoms of gadolinium toxicity that have not, as yet, been recognized by the FDA or medical community as being caused by retained gadolinium (Gd). Enter your email address to follow this blog and receive notifications of new posts by email. Most of the gadolinium toxicity affected patients I know describe their chronic pain as a dull, continuous ache, and as burning, numbness, prickling sensations, electric-like feelings, and/or deep bone pain in their hips, joints, and ribs. Instead of woodiness, doughiness; instead of redness, pinkness; instead of extreme joint contractures, stiffness of joints and decreased range of motion. If we had known from the beginning in 1997 that retained gadolinium was the cause, maybe it would have been called gadolinium toxicity or gadolinium poisoning and not NFD or NSF. Absence of potential gadolinium toxicity symptoms following 22,897 gadoteric acid (Dotarem®) examinations, including 3,209 performed on renally insufficient individuals The symptoms experienced could vary and might not be uniform among all patients. Since we launched our website in 2014, there has been a significant amount of new research published that indicates that gadolinium is being deposited in the brain. 6. The authors noted that, to the best of their knowledge, the study is the first to investigate a correlation between small fiber degeneration and GBCA exposure. Marckmann and Skov noted that the “clinical picture of NSF is diversified” and “it varies from one patient to another and it varies over time“. However, I am concerned that the diagnostic criteria for GDD could result in some patients who have been affected by retained gadolinium not being recognized and properly diagnosed. Fill in your details below or click an icon to log in: You are commenting using your WordPress.com account. The long-term and cumulative effects of retained gadolinium in the brain and elsewhere are not as yet understood. Gadolinium levels in urine and gadolinium concentration in bone were found to have a non-significant relationship (R 2 = 0.11, p = 0.3). We know that retention of Gd has been demonstrated in humans, that unexplained symptoms are occurring, and the neuronal effects of Gd have been demonstrated experimentally. As we have said many times before, Gadolinium Toxicity is a “disease of degrees” which we believe causes a disease process of varying severity with NSF likely being the most severe manifestation of it, but there is no reason to think it will be the only one. Despite having evidence of prolonged gadolinium retention many months and even many years after their last MRI with a GBCA, those patients with only one or two chronic symptoms of gadolinium toxicity, or another disease such as MS, won’t meet the diagnostic criteria for GDD. Signs and symptoms of gadolinium toxicity or Gadolinium Deposition Disease include: Intense burning of the skin and skin substrate: This may be localized in the torso or extremities (arms or legs) or it may affect the entire body. The authors said that the “magnitude of the measured toxicity broadly increases as the kinetic stability of the contrast agent decreases, and the lower stability agents induce toxicity at concentrations that fall within the range detected in some autopsy patients”. www.GadoliniumToxicity.com. Interestingly, as you will see in my letter, many symptoms of SFN are the same as the clinical symptoms associated with nephrogenic systemic fibrosis (NSF), which makes sense to me since the cause is the same. Intense boring pain in bones or joints. ( Log Out /  In 2016, a paper was published that provided the initial description of what is being called Gadolinium Deposition Disease or GDD in patients with normal or near normal kidney function; the description was recently updated. By means of a symptom survey of 17 people with high urine levels of Gadolinium, we have provided a comprehensive review of this topic in Survey of the Chronic Effects of Retained Gadolinium from Contrast MRIs, which we encourage you to read. Burning, itching or severe sharp pai… These symptoms may represent part of the same process that is causing brain fog. We know from the NSF-related literature that gadolinium can cause a potentially fatal systemic disease process when it is retained in the human body. Their self-reported symptoms have recently been published. Some people also experience tingling and shaking. As Sherry et al. Before providing information about having your urine tested for Gadolinium, a few words about types of testing, urine collection, and results reporting are appropriate. Recently, patients who report that they suffer from chronic symptoms secondary to gadolinium exposure and retention created gadolinium-toxicity on-line support groups. Nephrogenic systemic fibrosis (NSF) Causes the skin and internal organs to harden. Thickening and hardening of the skin, typically on the arms and legs and sometimes on the body, but almost never on the face or head 3. The presence of the gadolinium-based contrast agent depositions in the brain and symptoms of gadolinium neurotoxicity - A systematic review. used a mouse model to assess intraepidermal nerve fiber density (IENFD) after injection of gadolinium-based contrast agents (GBCAs). Here we are in 2018, 21 years after a problem first became apparent and 12 years after it was linked to gadolinium-based contrast agents. Materials and methods: This HIPAA-compliant, IRB-approved study consisted of an anonymous online survey of patients who believe that they suffer from gadolinium toxicity. Mai 2018 2. They said that the “unusual clinical presentation and nonspecific histology means that it may be very hard to come to the NSF diagnosis in some patients. The 6 main clinical criteria for Gadolinium Deposition Disease, as described by Dr. Semelka are: 1. ( Log Out /  An expansion of described symptoms for GDD. Some describe it as a burning pain and as an extreme tightness feeling (like a tight bathing cap on their head). Symptoms often develop within a month or so of the MRI. If you would like to learn more about the symptoms of gadolinium toxicity, read our Survey of the Chronic Effects of Retained Gadolinium from Contrast MRIs report. These two properties provide differentiating features for this entity. Arising in early stage (early on after GBCA):  This can be any bones or any joints. GDD sufferers describe it as a head pain, and unlike any other type of head-ache they have previously experienced. Several of the papers cited by Marckmann were referenced in my 2012 letter to the FDA to make my point that gadolinium retention could happen to ALL patients and they could be adversely affected by it. In 2006, nine years after NSF/NFD was first diagnosed, the connection was made between NSF and gadolinium-based contrast agents (GBCAs) administered for MRIs. Change ), You are commenting using your Google account. Skin that may feel \"woody\" and develop an orange-peel appearance and darkening (excess pigmentation) 4. The reason for making my letter available to the public now is to inform doctors, researchers, and affected patients about gadolinium-related facts that do not seem to be widely recognized. Arising in early stage (early on after GBCA): Many terms have been used for this: mental confusion sounds more scientific, but brain fog gets the point across well and succinctly. Head pain (early on after GBCA). The authors made an important point that I believe should apply to all patients who have had MRIs with a GBCA. I believe the problem is Gadolinium Toxicity, and not NSF, or anything else. ( Log Out /  Symptoms are categorized as "A Symptoms" which are symptoms distinctive for GDD (also other heavy metal toxicities), and "B Symptoms" which are symptoms that are commonly observed but may also be seen in a variety of other conditions. Would that be easily detected on histological examination of tissue, or blood tests? My hope is that more research will be conducted that involves evaluation and testing of patients who have retained gadolinium and are experiencing SFN-like symptoms, which, until now, have been unexplained and perplexing to clinicians who are not familiar with the potential toxic effects of retained gadolinium. Muscle vibrations/twitching and pins and needles skin sensations generally reflect nerve disease (neuropathy). This retention of gadolinium in the human body has been termed “gadolinium storage condition”. Nephrogenic systemic fibrosis can begin days to months after exposure to gadolinium-containing contrast. Gadolinium is normally excreted by the body through the kidneys, but kidneys functioning less than optimally have trouble getting rid of all of the gadolinium, so toxic levels build up in the body’s tissues and organs, including the brain. Some sufferers of gadolinium toxicity have also reported other symptoms, including gastrointestinal issues, such as diarrhea and abdominal pain, and cardiac issues such as abnormal heart rhythms. They don’t connect the … After all, we have been down this road before with NSF/NFD. However, until this study, it was unknown whether GBCAs induce toxic effects on the cellular function of human neurons. As a possible additional marker for damage of small fibers, the appearance of terminal axonal swellings (TASs) was assessed. Retrieved from http://ard.bmj.com/content/69/11/1895.full.pdf, Marckmann, P., & Skov, L. (2009). Nephrogenic systemic fibrosis can begin days to months after exposure to gadolinium-containing contrast. Particularly as this experiment has been done on 300-400 million people who weren't aware of this, they were only warned it may retain if their kidney was damaged and it may then have fatal consequences in that case (NSF). On this page, we … As of August 2018, governing authorities still have not recognized that patients with normal kidney function are being harmed by the gadolinium they are retaining. Symptoms onset and severity could vary depending on how much gadolinium each person retained. Four weeks after injection, the mice were euthanized, and footpads were assessed using immunofluorescence staining. Testing for Gadolinium Toxicity. Gadolinium Deposition Disease (GDD) Can happen when gadolinium remains in the body for months or years. Could it just be that the connection has not yet been made, and when considered together, all these facts might explain how patients’ symptoms are being caused by retained Gd from gadolinium-based contrast agents (GBCAs)? The study involved 6 groups of 8 mice that were intravenously injected with one dose (1 mmol/kg body weight) of either a macrocyclic GBCA (gadoteridol, gadoterate meglumine, gadobutrol), a linear GBCA (gadodiamide or gadobenate dimeglumine), or saline. Information and conclusions presented here should not be interpreted as medical advice. “For all agents, the magnitude of the toxicity increases with concentration.” (more…), May 19, 2018 3:57 pm / 2 Comments on Head Pain is a diagnostic feature of Gadolinium Deposition Disease. July 20, 2020 6:21 pm / 5 Comments on Possible connection between GBCAs and Small Fiber Neuropathy. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/19744598 Olchowy C(1), Cebulski K(2), Łasecki M(1), Chaber R(3), Olchowy A(2), Kałwak K(4), Zaleska-Dorobisz U(1). Second, the symptoms experienced by the patient after GBCA administration must be new, and not preexisting. symptoms of Gadolinium Toxicity. I/we knew they were wrong about that, but because of what had been said repeatedly in the published literature, patients with normal kidney function could not convince doctors that their symptoms were connected to the MRI with contrast that they had. Even though impaired kidney function did not cause NSF, the focus remained on the “N” or nephrogenic part of NSF. noted in their 2009 paper, “A Primer on gadolinium chemistry”, one of the reasons why Gd3+ (gadolinium) is so toxic in biological systems, is because its ionic radius nearly equals that of Ca2+ (calcium), and because of that, gadolinium can compete with calcium in all biological systems that require Ca2+ for proper function. With the current status of understanding gadolinium toxicity by the medical community, there is no known or verified methods to know with absolute certainty if you are gadolinium toxic or have symptoms that are caused by the element. The literature also indicates that gadolinium is neurotoxic, nephrotoxic, and cytotoxic, it inhibits mitochondrial function, induces oxidative stress, triggers endoplasmic reticulum stress, increases vascular reactivity, induces macrophage apoptosis, causes fatty liver, is a potent blocker of calcium channels, and more. Gadolinium Deposition Disease (GDD) refers to patients with gadolinium accumulation having normal kidney function that show painful symptoms within few hours or weeks or two months after exposure to Gadolinium based contrast agents (GBCAs). The symptoms of Gadolinium Toxicity can include: Pain in the arms and legs Symptoms of Gadolinium Toxicity: Can their cause be explained? Epub 2018 Oct 1. After reading the paper, it is evident that not all NSF patients presented clinically the same way. Since the medical community believes these contrast dyes are harmless, many don’t trace their symptoms back on their timeline to their scan. 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